Белок TRIM37 обладает противовирусной активностью к ВИЧ-1

Trim 5α was the first member of the tripartite motif (TRIM) family of proteins that was identified to potently restrict human immunodeficiency virus type 1 (HIV-1) replication. The breadth of antiretroviral activity of TRIM family members is an active area of investigation. In this study, we demonstrate human Trim 37 possesses anti-HIV-1 activity. This antiretroviral activity and the manner in which it was displayed was implicated by i) decreased viral replication upon Trim 37 transient overexpression in virus-producing cells, ii) correlation of the reduction of viral infectivity with Trim 37 virion incorporation, iii) increased HIV-1 replication during siRNA depletion of Trim 37 expression, and iv) reduction in viral DNA synthesis upon Trim 37 transient overexpression. Our findings provide the first demonstration of the potent antiviral activity of human Trim 37, and implicate an antiviral mechanism whereby Trim 37 interferes with viral DNA synthesis.