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31 octombrie 2016, 07:17
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Incidence of anal cancer has risen among MSM as people with HIV live longer

Incidence of anal cancer has risen among MSM as people with HIV live longer - poză 1

In the absence of national screening guidelines, only 11% of HIV-positive gay and bisexual men in the U.S. received anal Pap smears to detect anal cancer or precancerous cell changes during 2009-2012, with disparities between patient groups and variations across centers, according to a presentation at IDWeek, taking place this week in New Orleans.

 

Human papillomavirus (HPV) infection, anal dysplasia (abnormal cell changes), and anal cancer are more prevalent among HIV-positive men who have sex with men (MSM) than in the general population, and studies have found that the incidence of anal cancer has risen as people with HIV live longer thanks to effective antiretroviral therapy.

Mark Freedman and colleagues from the Centers for Disease Control and Prevention analyzed data from the 2009-2012 Medical Monitoring Project (MMP), which conducted interviews and extracted information from medical records for a representative sample of HIV-positive adults receiving care in the U.S. They asked what patient and provider characteristics are associated with anal cancer screening and whether men with anal cancer risk factors were more likely to be screened.

There are currently no U.S. guidelines for anal cancer screening of HIV-positive MSM using Pap cytology (examining a cell sample) or high-resolution anoscopy (inspecting the anal region using a lighted, magnifying instrument), Freedman noted as background. Prior studies have shown mixed results regarding the clinical utility, cost-effectiveness, and impact on survival of cytology testing, and there are not enough healthcare providers trained to perform anoscopy.

The researchers looked at 914 gay and bi men who underwent anal cancer screening during the past 12 months and 7470 men who had not been screened or had no record of whether they had or not. The analysis compared demographics, clinical status, behavior, and facility characteristics.

Results

  • 11% of HIV-positive MSM were screened for anal cancer nationwide during the past year (95% confidence interval 9%-13%).
  • Black men were significantly less likely to be screened than white or Latino/Hispanic men (7% versus 13% and 12%, respectively).
  • Men under age 40 were somewhat less likely to be screened, but the difference did not reach statistical significance (p=0.08).
  • There were no significant differences related to education level, type of health coverage, or duration of HIV infection.
  • Regarding risk factors, men who smoked were significantly less likely to be screened than non-smokers (10% versus 12%, respectively) -- even though smoking is a known risk factor for anal cancer and other HPV-associated malignancies.
  • Among men who said they'd had receptive anal sex, 13% were screened, compared to 10% of those not reporting anal sex, a highly significant difference.
  • Among men tested for sexually transmitted diseases, those diagnosed with any STD were a bit more likely to undergo anal cancer screening than those not so diagnosed (14% versus 19%, respectively), but again the difference was not significant.
  • Turning to health facility characteristics, just 4% of facilities that provided care for fewer than 50 patients offered anal cancer screening, compared to 14% of large practices serving more than 400 people.
  • No differences were seen according to public versus private ownership of facilities or receiving Ryan White funding.

These findings show that only a small proportion of gay and bi men receive regular anal cancer screening. Even among the groups with the highest rates, the percentage never reached 20%.

Numerous prior studies have found that black people are less likely to enter and be retained in HIV care as compared with whites, but this analysis found a racial disparity even among people who are currently in care

Noting that guidelines recommending cervical cancer screening have dramatically reduced morbidity and mortality among women -- including HIV-positive women -- Freedman suggested that anal cancer screening might be similarly beneficial for HIV-positive gay men.

Source

M Freedman, J Weiser, LR Beer, and RL Shouse. Anal Cancer Screening in Men who have sex with Men in Care for HIV infection, United States, 2009-2012." IDWeek. New Orleans, October 26-30, 2016. Abstract 855.

Autor: Marina Shegay

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