HIV neutralizing antibodies show promise
A collaborative team of German and American scientists published results of successful test of the HIV neutralizing antibody 10-1074. This new generation of highly potent antibodies is able to neutralize a number of HIV strains. The research group is investigating if the antibody can be used to treat HIV infection.
The antibody targets a specific structure in the protein envelop and in the study, it was well tolerated. It showed high antiviral activity in HIV infected participants and the study was able to investigate development of resistant HIV variants. Further trials are scheduled for the spring.
"This trial was only possible because of the intensive collaboration with the Rockefeller University and many other clinical and scientific partners," says Prof Klein, principal investigator in Germany and co-last author of the study.