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24 April 2017, 15:36
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97% Cures of Genotype 3 Hep C In Glecaprevir and Pibrentasvir Combination

97% Cures of Genotype 3 Hep C In Glecaprevir and Pibrentasvir Combination - picture 1

AbbVie's pangenotypic direct-acting antiviral combination of two drugs - glecaprevir and pibrentasvir - cured 97% of people with early-stage genotype 3 hepatitis C virus (HCV), the hardest genotype to treat, according to results of the ENDURANCE-3 trial presented at the International Liver Congress in Amsterdam on Friday.

The AbbVie second-generation direct-acting antiviral combination consists of a protease inhibitor and an NS5A inhibitor. Glecaprevir is an HCV NS3/4A protease inhibitor active against all genotypes of hepatitis C. Pibrentasvir is an NS5A inhibitor also active against all genotypes of hepatitis C.

A pangenotypic combination should be similarly effective against all genotypes of hepatitis C. Direct-acting antiviral combinations have tended to show slightly lower efficacy in people with genotype 3 to date. Patients with cirrhosis or with previous experience of treatment – the hardest to treat.

The ENDURANCE-3 study was planned to test the combination of glecaprevir and pibrentasvir in people with genotype 3 infection without cirrhosis, stated Professor Graham Foster of Queen Mary University, London.

Genotype 3 is especially prevalent in South Asia and in South Asian populations in the United Kingdom, but these patients tend to have more advanced disease. Genotype 3 is also found in people who inject drugs, and most recent infections in Europe and North America occur in people who inject drugs.

“Genotype 3 is spreading in the US among young injectors, especially young men. For every patient that we treat and cure, that’s ten of his friends who don’t get infected,” said Prof. Foster.

Author: Lilia Ten

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